Skip to main content
| | | Screen Reader Access |   
   |   
  • Novel Furanyl-Substituted Isochromanyl Class of Anti-Inflammatory Turbinochromanone

    Organic extract of the brown seaweed Turbinaria conoides (Sargassaceae) was chromatographically fractionated to yield an undescribed furanyl-substituted isochromanyl metabolite, named as turbinochromanone, which was characterized as methyl 4-[(3S)-8-{[(3R)-4-ethyl-2,3-dihydrofuran-3-yl]methyl}-1-oxo-3,4-dihydro-1H-2- benzopyran-3-yl]butanoate. The isochromanyl derivative possessed comparable attenuation potential against 5- lipoxygenase (IC50 3.70 ?M) with standard 5-lipoxygenase inhibitor drug zileuton (IC50 2.41 ?M). Noticeably, the index of anti-inflammatory selectivity of turbinochromanone (~1.7) was considerably greater than that exhibited by the standard agent diclofenac (1.06). Antioxidant properties of turbinochromanone against oxidants (IC50~24 ?M) further supported its potential anti-inflammatory property. Greater electronic properties (topological polar surface area of 61.8) along with comparatively lesser docking parameters of the studied compound with aminoacyl residues of targeted enzymes (cyclooxygenase-2 and 5-lipoxygenase) (binding energy of 11.05 and 9.40 kcal mol^1, respectively) recognized its prospective anti-inflammatory potential. In an aim to develop seaweed-based natural anti-inflammatory leads, the present study isolated turbinochromanone as promising 5-lipoxygenase and cyclooxygenase-2 inhibitor, which could be used for pharmaceutical and biotechnological applications.


    Read More...

  • Transcriptomic footprint of Mytella strigata: de novo transcriptome assembly of a major invasive species
  • Discovery of a new species of troglobitic eel loach from southern India
  • Reproductive biology of largehead cutlassfish Trichiurus lepturus Linnaeus 1758 along eastern Arabian Sea and western Bay of Bengal
  • Sulfated exopolysaccharide from Bacillus altitudinis MTCC13046 accelerates cutaneous wound healing via dermal fibroblast migration: Insights into an in vivo wound re-epithelialization
  • Unveiling the economic burden of diseases in aquatic animal food production in India
  • Morphometrics, Length-Weight Relationships and Relative Condition Factor Inportunus Sanguinolentus (Herbst, 1783) from Southeastern Arabian Sea
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img

Search...