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  • Non-sulfated steroidal glycosides cistoindosides from marine old woman octopus Cistopus indicus attenuate pro-inflammatory lipoxygenase

    Two non-sulfated steroidal glycosides, cistoindosides A-B were isolated from organic extract of the marine ‘old woman octopus’ Cistopus indicus (family Octopodidae).The anti-inflammatory properties were corroborated by the promising antioxidant activities  of these steroid glycosides. Sizeably greater electronic properties, balanced hydrophobic-lipophilic properties  and comparatively lower steric factors were directly proportional to their bioactivities. Molecular simulation studies in the active sites of 5-lipoxygenase displaying lesser binding energies and inhibition constant (Ki) of cistoindoside B could be correlated with anti-inflammatory properties. Cistoindosides could be projected for their utilization as potential bioactive leads in functional food and pharmaceutical applications.

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