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  • Euryfuranyl compounds from edible species of cuttlefish as potential anti-inflammatory leads attenuating NF kB signaling cascade

    Nuclear factor-kappa B is an inducible transcription element, which was considered as an important regulator of immune functions, and plays a critical role to induce inflammatory reactions. In this study, we have demon- strated the anti-inflammatory potentials The euryfuranyl analogue (1) down-regulated the mRNA expression of cyclooxygenase-2 and nuclear factor-?B signaling pathway in lipopolysaccharide-activated macrophage cells by hindering the degradation of inhibitor-?B proteins, and transfer of the subunit NF kB p65 to the nucleus from the cytosol. These results demonstrated that the euryfuranyl analogue could be explored as a promising anti-inflammatory therapeutic lead attenuating nuclear factor-?B signaling cascade.


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