Skip to main content
| | | Screen Reader Access |   
   |   
  • Aryl-enclosed polyketides from mangrove sediment associated bacterium Bacillus amyloliquefaciens

    Two aryl-enclosed polyketides were identified from the ethyl acetate extract of mangrove sediment associated bacterium Bacillus amyloliquefaciens, and were characterized as 1-(8-hydroxy-1-oxoisochroman-3-yl)propyl 4?-(6?-hydroxy-8?- oxotetrahydrofuran-5?-yl)acetate (compound 1) and 6?a-(3?-(1?-(8-hydroxy-1-oxoisochroman-3-yl)propoxy)-3?-oxoethyl)- 8?-oxotetrahydrofuran-6?-yl butyrate (compound 2) by detailed spectroscopic techniques encompassing two-dimensional nuclear magnetic resonance and mass spectroscopic experiments. Polyketide compound 2 bearing oxotetrahydrofuran-6?-yl butyrate moiety exhibited potential antioxidant activities against the free radicals, 2,2-diphenyl-1-picrylhydrazyl radical and 2,2?-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (IC50 1.01 and 1.22 mM, respectively), and were found to be significantly greater than those displayed by polyketide 1 and standard (?-tocopherol IC50 1.45–1.63 mM, p < 0.05). Compound 2 also exhibited greater anti-inflammatory properties as determined by 5-LOX inhibitory assay (IC50 1.11 mM) than those displayed by compound 1 (IC50 1.23 mM) and standard (ibuprofen IC50 4.50 mM). Greater electronic parameters of compound 2 could further support its greater bioactive potentials.


    Read more...

  • Transcriptomic footprint of Mytella strigata: de novo transcriptome assembly of a major invasive species
  • Discovery of a new species of troglobitic eel loach from southern India
  • Reproductive biology of largehead cutlassfish Trichiurus lepturus Linnaeus 1758 along eastern Arabian Sea and western Bay of Bengal
  • Sulfated exopolysaccharide from Bacillus altitudinis MTCC13046 accelerates cutaneous wound healing via dermal fibroblast migration: Insights into an in vivo wound re-epithelialization
  • Unveiling the economic burden of diseases in aquatic animal food production in India
  • Morphometrics, Length-Weight Relationships and Relative Condition Factor Inportunus Sanguinolentus (Herbst, 1783) from Southeastern Arabian Sea
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img
  • img

Search...