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  • Apoptotic effect of chromanone derivative, hyrtiosone A from marine demosponge Hyrtios erectus in hepatocellular carcinoma HepG2 cells

    The tumor suppressor proteins p53 and p27 exhibited a significant role in the survival of cells and regulation of cellular division and growth. In majority of the human tumors, particularly in hepatocellular carcinoma, these proteins are inactivated by mutation or deletion, and are considered to predict the pathophysiology related to liver cancer. The present study evaluated the activation of the p53 and p27 pathways as a useful therapeutic tool to attenuate hepatocellular carcinoma. Three undescribed homologous chromanone derivatives, hyrtiosones A C were isolated from the organic extract of marine demosponge Hyrtios erectus. Preliminary bioactivity assessments found that hyrtiosone A exhibited prospective anti inflammatory and antioxidant properties. Molecular docking analysis of the hyrtiosones using p53-murine double minute complex revealed lesser docking parameters for hyrtiosone A


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  • Transcriptomic footprint of Mytella strigata: de novo transcriptome assembly of a major invasive species
  • Discovery of a new species of troglobitic eel loach from southern India
  • Reproductive biology of largehead cutlassfish Trichiurus lepturus Linnaeus 1758 along eastern Arabian Sea and western Bay of Bengal
  • Sulfated exopolysaccharide from Bacillus altitudinis MTCC13046 accelerates cutaneous wound healing via dermal fibroblast migration: Insights into an in vivo wound re-epithelialization
  • Unveiling the economic burden of diseases in aquatic animal food production in India
  • Morphometrics, Length-Weight Relationships and Relative Condition Factor Inportunus Sanguinolentus (Herbst, 1783) from Southeastern Arabian Sea
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