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CMFRI commercialized Nutraceuticals for use against arthritis, type-2 diabetes and hypertension

ICAR-CMFRI commercialized Nutraceuticals for use against arthritis, type-2 diabetes and hypertension to Pioneer Pharmaceuticals Limited-a leading wellness and Pharmaceutical Company based at Kochi

CadalminTM Green Algal extract (CadalminTM GAe), Antidiabetic extract (CadalminTM ADe), and Antihypertensive extract (CadalminTM AHe), three patent-protected nutraceutical products developed by ICAR-Central Marine Fisheries Research Institute, as natural remedies for joint pain/arthritis, type-2 diabetes and hypertensive disorders from seaweeds, were commercialized with Pioneer Pharmaceuticals Limited-a leading wellness and pharmaceutical company based at Kochi. Seaweeds are the natural bounty of the Sea, and are known for their extraordinary medicinal properties. 

Dr. A. Gopalakrishnan, Director, ICAR-CMFRI signed an exclusive license agreement with Mrs. Nancy Joby (Managing Partner), along with Mr. Joby George, Joel Joby George, Mathews Simon and B.C Kumar on 9th September for their commercial production and marketing.


Nutraceuticals for use against arthritis, type-2 diabetes and hypertension


Seaweeds are commonly available in the Indian coastal waters, and are gaining immense attention in nutraceutical industries due to their protective function against various chronic diseases


Bioactive principles in CadalminTM GAe competitively inhibit pro-inflammatory cyclooxygenase-2 and lipooxygenase, resulting in decreased production of inflammatory prostaglandins and leukotrienes, thereby hindering the occurrence of inflammatory pain and arthritis. Bioactive pharmacophore leads from seaweeds were used to develop CadalminTM AHe, which can be administered to regulate clinical indicators leading to pathophysiology leading to hypertension that is one of the risk factors for strokes, heart attacks, heart failure, and arterial aneurysm, and is a leading cause of chronic kidney failure. The bioactive ingredients in CadalminTM AHe blocks angiotensin converting enzyme that converts angiotensin I to angiotensin II.  Decreased production of angiotensin II enhances natriuresis, lowers blood pressure, and prevents remodeling of smooth muscle and cardiac myocytes. The bioactive ingredients in CadalminTM AHe also effectively modulate the serum level of oxidative stress marker nitric oxide, lipid peroxidase and the potent vasoconstrictor angiotensin-II.

CadalminTM ADe, an anti-diabetic nutraceutical to combat type-2 diabetes, contains 100% natural marine bioactive ingredients extracted from seaweeds by a patented technology. The bioactive ingredients in CadalminTMADe competitively inhibit dipeptidyl peptidase-IV and tyrosine phosphatase 1B, thereby hindering the occurrence of type-2 diabetes. The active ingredients interfere with the release of simple sugars from the gut, which in turn reduces postprandial (after eating) hyperglycemia (high blood sugar levels). 

These nutraceutical products contain 100% natural marine bioactive ingredients from selected seaweeds by patented technologies, and would be made available in 400 mg plant-based capsules to meet the dietary needs of the large vegetarian population in India and abroad, by Pioneer Pharmaceuticals Limited. Preclinical trials showed no side-effects and toxicity related significant changes in the mammalian subjects. 

These nutraceutical products were prepared from seaweeds, which are commonly available in the Indian coastal waters. The ICAR-CMFRI is in the process of developing more health products from seaweeds towards their utilization based on the National Policy to harness the potential of this natural wealth of Indian coastal waters. 

Seaweeds are commonly available in the Indian coastal waters, and are gaining immense attention in nutraceutical industries due to their protective function against various chronic diseases. Indian nutraceuticals market has been growing at the compound annual growth rate of 20 per cent for the past three years, particularly in the segments of functional food. These developments point towards the fast proliferation of the specific segments of nutraceuticals in India and its acceptance by the Indian consumers and healthcare providers. 

These products will be manufactured and marketed by Pioneer Pharmaceuticals Limited, Kochi.

Advisory support to fish farmers during Lockdown due to COVID-19

Scientists  available to provide guidance over phone/mail/ Whattsapp, to the fish farmers during Lockdown due to COVID-19.

Sl.No

Name

Designation

Subject

Mob. Number

Email

1

Dr Vinod, K

Principal Scientist

Ecosystem health/ Biodiversity conservation

9496475596

 

vinod_kavungal@yahoo.co.in

2

Dr Shilta, M. T

Scientist

Cage culture

8075389216

Shiltathomas@gmail.com

3

Dr P.K.Asokan

Principal Scientist

Bivalve farming

9447137278

 asokanpk@gmail.com

4

Dr. Ritesh Ranjan

Scientist

Mariculture

9494436445

rranjanfishco@gmail.com

5

Dr. Santhosh B

Principal Scientist

Mariculture

9446572288

santhoshars@gmail.com

6

Shri. Ambarish

Scientist

Mariculture

9847553047

gopidas.ambarish@gmail.com

7

Dr. Rengarajan  Jayakumar

Principal Scientist

Marine fish farming

9489036516

jayakumar.cmfri@gmail.com

8

Dr. K.K. Anikuttan

Scientist

Marine fish farming

9751865267

dranikuttan@gmail.com

9

Dr. G. Tamilmani

Senior Scientist

Marine Fish Breeding

9486221352

drtamilmani@gmail.com

10

Dr. M. Sakthivel

Senior Scientist

Sea cage farming

9488266503

sakthicares@gmail.com

11

Dr. P. Ramesh Kumar

Scientist

Fish Health

9659384485

prkvet@gmail.com

12

Dr.Shinoj Subramannian

Senior Scientist/SIC KVK of CMFRI Ernakulam

Krishi Vigyan Kendra of CMFRI, Ernakulam

9496303457

kvkernakulam@yahoo.co.in

13

Dr.Vikas PA

Subject Matter Specialist,  KVK of CMFRI Ernakulam

Fisheries

9447993980

vikaspattathh@gmail.com



 

 

ICAR-CMFRI launches GIS based info of vicinity of fish landing centres to COVID-19 hotspots

 ICAR-CMFRI launches GIS based info of vicinity of fish landing centres to COVID-19 hotspots

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The ICAR-Central Marine Fisheries Research Institute (CMFRI), Kochi has launched a novel initiative that would enable online GIS tracking of the marine fish landing centres and their proximity to the COVID-19 hotspots in different maritime states. The online GIS based database, which depicts the vicinity of marine fish landing centres to the COVID-19 hotspots in Kerala, Andhra Pradesh and Karnataka, would become crucial in monitoring the activities at various marine fishing landing centres in the country on a daily basis. The work is in progress to incorporate the information on landing centres in other maritime states too in the database. The database offers visualisation of the marine fish landing centres in these states in various colour groups in accordance with their geographical proximity with the COVID-19 hotspots/containment zones within coastal districts, identified by the government. The landing centres have been categorised in different groups according to their distance with the hotspots and the information is updated on daily basis based on the information received from respective state governments.

 

The first category, which requires priority in taking precautionary measures, includes fish landing centres located within 3 km of the hotspot. The landing centres at a distance of 3 to 5 km with the hotspots fall in second category, whereas the third category includes landing centres at a distance of 5 to 10 km from the identified hotspots.

 


Practical utility of the initiative: The GIS database will greatly help authorities and policy makers to monitor the daily activities and help them easily understand the fish landing centres where strict safety measures are to be imposed and fish harbours where safety measures could be relaxed. This can be identified simply by a click at the infographics published by the ICAR-CMFRI at its website- www.cmfri.org.in. This will help the concerned authorities for strategic execution of safety measures in accordance with their vicinity to the COVID-19 hotspots.

 

The news has got immediate international attention and quoted as one of the top stories of the day by SeafoodSource.com,the global seafood industry’s most trusted resource for international seafood news (https://www.seafoodsource.com/news/food-safety-health/online-directory-of-india-s-fish-landing-centers-proximity-to-covid-19-hotspots-published).

 


* * * CMFRI Infographics * * *

Vicinity of Fish Landing Centres to COVID-19 Hotspots in Kerala



ICAR-CMFRI kick-starts new farming challenge towards food security

ICAR-CMFRI kick-starts new farming challenge towards food security

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The ICAR-Central Marine Fisheries Research Institute (CMFRI), in association with the Ernakulam Krishi Vigyan Kendra, kick-started a new farming challenge among government organisations towards food security. The model initiative includes farming of tubers and pulses along with vegetables in an area of around 3-acre barren land in its premises of residential complex in Kochi city. The massive drive assumes significance in the wake of discussions on urgent need of self-reliance in food production in Kerala, thanks to COVID-19 pandemic.   

Shri. V S Sunil Kumar, Minister for Agriculture, Kerala government launched the farming by planting ginger saplings on 14th May 2020. The farming, which is undertaken by ICAR-CMFRI Krishilokam club that includes scientific and non-scientific staff of the Institute and their families, is part of popularising the concept of production of safe food through farming without depending others in the backdrop of the COVID-19. The farming followed mechanised practices for preparation of the land under the technical guidance of Ernakulam KVK.